Ensure Plus nutrition shakes are clinically proven to help gain weight. Each shake contains 16 grams of high-quality protein, 350 calories, 27 vitamins and minerals, and nutrients to support immune system health, including vitamins A and D, zinc, and antioxidants. Ensure Plus protein shakes provide complete, balanced nutrition and are a great meal replacement option. Vitamins C and E. Ensure Plus = 16 g protein per 8 fl oz vs Ensure original = 9 g protein per 8 fl oz. Contains 11g total fat per serving.